My work explores arterial function, one-carbon metabolism, and other cardiovascular risk factors in their distribution and association with event outcomes. I have focused on developing prevention and management strategies for improving cardiovascular and cerebrovascular health using population-based evidence and epidemiological analysis methods to serve public health and clinical interests. I believe that assessing vascular conditions requires systematic knowledge of the underlying pathophysiological mechanisms in addition to the usual individual risk factors. I’m also interested in understanding vascular health from an evolutionary perspective.